Meet Fiona, a Myriad Oncology patient, who has taken a MyRisk® Hereditary Cancer test

MyRisk® Hereditary Cancer Test

Recommended genes only – grounded in strong clinical evidence. That’s the MyRisk Test standard.

The MyRisk Test evaluates 63 clinically recommended genes grounded in strong clinical evidence to reveal hereditary cancer risks and treatment-impacting variants across more than 11 cancer types, empowering you to personalize care plans with confidence.

Are you missing critical insights that could impact cancer care?

The MyRisk Test focuses exclusively on genes backed by clinical evidence and cited in national oncology guidelines—so every result has the potential to inform care.1-3

100%

of genes strongly recommended by ASCO guidelines are tested to help ensure no relevant findings are missed1-3

100%

of genes tested are cited in national oncology guidelines, helping to avoid the uncertainty associated with non-actionable result1-3

Designed to evolve with clinical evidence

Gene-disease associations and medical management recommendations are updated regularly based on the latest clinical evidence, helping ensure your results are meaningful, actionable, and appropriate for clinical use.

Enhanced insights at every step of the cancer care continuum

Inform treatment decisions right from diagnosis

The MyRisk Test provides you with more critical answers for more patients by definitively classifying up to 63% of variants that other labs could not.4

Unlock targeted therapy opportunities

Did you know that up to 10% of germline variants are missed by tumor testing alone?2 The MyRisk Test identifies germline BRCA1/2 variants that may impact use of targeted therapies such as PARP inhibitors.5,6

Identify risk of secondary cancer and personalize management

The MyRisk Test identifies hereditary cancer syndromes associated with a risk for secondary cancers, directly impacting treatment decisions to reduce the occurrence of subsequent cancer.

Get results within 14 days, and as fast as 7 days with the MyRisk STAT priority ordering option.

Graphic showing the how MyRisk® Germline test can guide treatment decisions, including targeted therapy options and identify the risk for secondary cancer

Germline testing info graphic

Choose the most actionable and guideline-driven commercially available multigene germline core panel1-3

National guidelines recommend germline testing as part of the workup for patients diagnosed with ovarian, breast, pancreatic, prostate, and colon cancer.1 Additionally, while genomic testing has long been recommended for all patients diagnosed with metastatic or advanced cancers, the American Society of Clinical Oncology (ASCO) now advises multigene germline testing for patients who meet criteria regardless of their tumor results.2

  • The MyRisk Test is the only germline core panel that tests for 100% of genes strongly recommended by ASCO guidelines.1-3
  • As opposed to most commercially-available germline multigene panels, the MyRisk Test doesn’t assess genes that are not recommended by national guidelines – helping to avoid the uncertainty associated with non-actionable results.1-3
  • The MyRisk Test only tests for recommended genes and provides medical management recommendations where available.1-3

Who is The MyRisk Test for?

Image showing the Myriad Oncology MyRisk test kit

The MyRisk Test is appropriate for patients with a personal and/or family history of certain cancers, including:

  • Breast cancer*
  • Ovarian cancer
  • Prostate cancer
  • Pancreatic cancer*
  • Uterine cancer
  • Colorectal cancer*
  • Skin cancer
  • Gastric cancer
  • Renal cancer
  • Lung cancer
  • Endocrine cancer
  • Other

*Eligible for MyRisk STAT, except for patients with government insurances, including but not limited to Tricare Prime, Medicaid, Indian Health Services, VA, etc.

One test. One report. Everything you need.

The MyRisk Test analyzes 63 genes linked to more than 11 cancer types.

Every MyRisk Test report includes:

  • Germline results with clinically significant mutations found, including variants of uncertain significance (VUS)
  • Summary of clinical, personal, and family cancer history
  • The MyRisk Management Tool, providing risk estimates, critical information for treatment decisions based on test results, as well as personalized medical management recommendations in line with current guidelines
  • Information to help family members understand their potential genetic risk
Image of sample positive, elevated, and negative MyRisk® Hereditary Cancer Test results
Positive result icon

Positive Result

A mutation has been identified.

Elevated result icon

Elevated Result

An elevated risk has been identified.

Negative result icon

Negative Result

No clinically significant mutation.

Variant of uncertain significance result icon

Variant of Uncertain Significance

Mutation of uncertain risk has been identified.

Paired DNA and RNA genetic testing that goes beyond patients’ initial test results

The MyRisk Test, combined with Myriad’s industry-leading Variant Classification Program,6 utilizes RNA testing strategically, along with other proprietary tools, to deliver highly accurate variant interpretations, ensuring precise and actionable results for more patients.

Classifies most variants through advanced baseline DNA analysis—without the need for upfront RNA testing 4,6

Industry’s lowest reported VUS rates for BRCA1 and BRCA2 of 0.3% and 0.7%, respectively6

Our Lifetime Classification Commitment sends amended reports whenever a patient’s MyRisk VUS result is reclassified as clinically significant

The MyRisk Test definitively classifies
up to 63%
of variants other labs could not4

RNA analysis delivers cutting-edge innovation

Myriad pioneered the use of RNA analysis in 2015 and offers RNA analysis to all patients with an eligible VUS. When RNA analysis is performed, our methodology allows us to classify variants with precision, at no additional cost ,and often without the need for a re-draw.7,8

Fast, seamless ordering and reporting

The MyRisk Test is available through leading EMR platforms, including Epic and OncoEMR—streamlining ordering and result access within your existing workflow.

Provider completes the test request form (in the EMR system, portal or via paper TRF)

Provider completes the test request form (in the EMR system, portal or via paper TRF)

Patient blood or saliva sample is collected and submitted to Myriad Genetics with the test kit

Patient blood or saliva sample is collected and submitted to Myriad Genetics with the test kit

Results are sent to the ordering provider (in the EMR system, portal, or via mail)

Results are sent to the ordering provider (in the EMR system, portal, or via mail)

MyRisk STAT:

Right surgery. Right answer. Right now.

There should not be a trade-off between turnaround time and receiving an accurate, comprehensive risk assessment when determining surgical treatment for patients. MyRisk STAT was developed for trusted results without the wait.

7 days

MyRisk STAT test results for eligible patients diagnosed with breast, pancreatic or colorectal cancer.

<14 days

Results delivered for all other patients

Image showing Myriad Oncology’s portfolio of germline and tumor genomic test kits

All your Myriad Oncology testing and results in OncoEMR​

If you already count on the MyRisk Test, you’ll soon have even more reason to choose Myriad.

We’ve brought the Precise Tumor®, MyChoice® CDx Myriad HRD Companion Diagnostic Test, and immunohistochemistry (IHC) testing for PD-L1 and FOLR1/FRa into your OncoEMR workflow, so you can order germline and tumor genomic tests in one seamless process, from a single lab.​

Myriad Oncology empowers you to transform patient care

For a complete approach to cancer risk management and treatment planning, the MyRisk Germline Test can be combined with tumor genomic testing to deliver powerful results informing patient care across the entire care continuum—from assessing hereditary cancer syndromes to helping guide treatment decisions.

Precise Tumor Molecular Profile Test MyRisk Hereditary Cancer Test

For your patients with advanced cancer, combine germline and tumor genomic insights to identify hereditary cancer risks and actionable mutations, enabling personalized treatment plans and targeted therapies. The MyRisk Test and Precise Tumor Test focus on clinically relevant variations in the genome, using powerful and unique classification tools, including targeted RNA analysis, to deliver accurate variant interpretations.

Endopredict Breast Cancer prognostic Test MyRisk Hereditary Cancer Test

For your patients with early-stage breast cancer, pair germline testing with tumor genomic insights and breast cancer recurrence assessment to guide personalized decisions on risk-reducing surgeries and adjuvant therapy strategies.

MyChoice companion diagnostic MyRisk Hereditary Cancer Test

For your patients with ovarian cancer at any stage, integrate germline and tumor genomic insights with tumor homologous recombination deficiency (HRD) testing to inform comprehensive treatment options with PARP inhibitors.

Myriad Oncology’s portfolio of products delivers:

  • Integrated genetic and tumor genomic insights to personalize care for each cancer patient
  • Confident risk and recurrence assessments to inform both preventive and therapeutic decisions
  • Streamlined reporting to prioritize actionable insights at every step of the cancer journey

What to expect with every MyRisk Test

Actionable

The MyRisk Test delivers treatment-focused reporting with actionable summaries, providing clear insights for surgical and treatment decisions to support more confident patient care.

Accurate

The MyRisk Test delivers unmatched accuracy, with variant classification techniques independently verified and clinically validated at >99.9% accuracy.5

Affordable

Transparent pricing with personalized cost estimates, financial assistance, and other affordability options, including direct pay.
Learn more

TAKE THE NEXT STEP WITH THE MYRISK TEST

Learn more about our tests or explore ordering options to bring the MyRisk Test to your practice.

Get started with Myriad Oncology

Request more information about how Myriad’s Oncology solutions can benefit you/your patients.


Don't know your NPI? Click Here

By submitting your personal information, you agree to be contacted with newsletters, marketing or promotional materials, and other information that may be of interest to you. You may opt-out of receiving communications from us by following the unsubscribe link or the instructions provided in the communication we send. For further information on our privacy practices and commitment to protecting your privacy, please visit our Privacy Notice.

Hidden Fields











Hidden test fields


Order a test

MyRisk resources

Patients with government payers (Medicare, Medicare Advantage, TriCare) are not eligible for MyRisk STAT.

References:
  1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines.) Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate. V1.2026. ©National Comprehensive Cancer Network, Inc. 2025. All rights reserved. Accessed September 4, 2025. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
  2. Tung N, Ricker C, Messersmith H, et al. Selection of Germline Genetic Testing Panels in Patients With Cancer: ASCO Guideline. J Clin Oncol. 2024;42(21):2599-2615.
  3. Internal product development data on file at Myriad Genetics, Inc. Last updated 2025.
  4. Gradishar W, Johnson K, Brown K, et al. Clinical Variant Classification: A Comparison of Public Databases and a Commercial Testing Laboratory. Oncologist. 2017;22(7):797-803.
  5. Judkins T, Leclair B, Bowles K, et al. Development and analytical validation of a 25-gene next-generation sequencing panel that includes BRCA1 and BRCA2 genes to assess hereditary cancer risk. BMC Cancer. 2015;15:215.
  6. Mundt E, McGreevy K, Nix P, Cummings S. Myriad’s Multidisciplinary Approach and Consistent Investment in Variant Classification for Clinical Decision Making [White paper]. Myriad Genetics. 2025.
  7. Nix P, Mundt E, Manley S, Coffee B, Roa B. Functional RNA Studies Are a Useful Tool in Variant Classification but Must Be Used With Caution: A Case Study of One BRCA2 Variant. JCO Precis Oncol. 2020;4:730-735.
  8. Nix P, Mundt E, Cummings SA, Roa B, Enhancing variant interpretation in hereditary cancer testing with RNA analysis from residual blood samples. J Clin Oncol. 2025;43(16_suppl):e22595.

©Myriad Genetics, Myriad Oncology, MyRisk, Precise Tumor, MyChoice, Prolaris, BRACAnalysis CDx, RiskScore, and their respective logos, are either trademarks or registered trademarks of Myriad Genetics, Inc. and its subsidiaries in the United States and other jurisdictions. EndoPredict and the EndoPredict logo are either trademarks or registered trademarks of Eurobio Scientific.